One sample-level bias-reduced classifier with a locked held-out evaluation.

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Sample-level biomarker classification

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Fit a sample-level classifier with patient-grouped splits, then report held-out metrics once per patient.

Input

Sample-level expression, outcomes, and patient-grouped train/test assignments.

Analysis unit

Sample for model fitting; patient for train/test separation.

Outputs

Bias-reduced classifier and held-out patient metrics.

Key limit

Exploratory cohort analysis; external and clinical validation are not established.

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